Trogocytosis and cross-dressing in antigen presentation

P Schriek; JA Villadangos

Journal article

Trogocytosis and cross-dressing in antigen presentation

P Schriek, JA Villadangos

Current Opinion in Immunology | CURRENT BIOLOGY LTD | Published : 2023

DOI: 10.1016/j.coi.2023.102331

Abstract

Antigen (Ag)-presenting cells capture or synthesize Ags that are processed into peptides bound and displayed on the plasma membrane by major histocompatibility complex (MHC) molecules. Here, we review a mechanism that enables cells to present Ag-loaded MHC molecules that they have not produced themselves, namely trogocytosis. During trogocytosis, a cell acquires fragments from another living cell without, in most cases, affecting the viability of the donor cell. The trogocytic cell can incorporate into its own plasma membrane (becoming cross-dressed) proteins acquired from the donor cell, including intact Ag and MHC molecules. Trogocytosis and cross-dressing expand the immunological function..

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University of Melbourne Researchers

Jose Villadangos Author

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Grants

Awarded by Harvard University

Funding Acknowledgements

The authors thank Profs. Facundo Batista (Harvard University, USA) , Ana Maria Lennon-Dumenil (Curie Institute, France) , and Jon Yewdell (NIH, USA) for their answers to questions raised by the authors during preparation of this paper. JAV received funding from the National Health and Medical Research Council of Australia (1058193, 1058193, 1016629, and 1113293) , the Australian Research Council (DP110101383, DP160103134, and DP220102288) , and the Human Frontiers Science Program (0064/2011) . PS received an Australian Research Training Program Scholarship.